Type 3 Diabetes, Bacon shortage and Updates!

TheFatNurse is still alive and well! Yes It’s been awhile since TheFatNurse last posted but for good reason! TheFatNurse had a string of events involving midterms, classes, clinics and even a mini lecture TheFatNurse gave on cholesterol and heart disease at TheFatNurse’s uni! But now that is all over and done with so TheFatNurse is back and ready to step into the frying pan. Speaking of frying pans…a global bacon shortage was predicted during the two months TheFatNurse was out…truly the end of times.

In the last post TheFatNurse briefly covered glucose and brain atrophy, well another related news story occurred in USATODAY about carbohydrate consumption and alzheimers!

Older people who load up their plates with carbohydrates have nearly four times the risk of developing mild cognitive impairment, a study out Tuesday finds. Sugars also played a role in the development of MCI, often a precursor to Alzheimer’s disease, according to the report in the Journal of Alzheimer’s Disease. Eating more proteins and fats offer some protection from MCI.

Whoa…what! TheFatNurse isn’t shocked by the news of carbohydrates being linked to MCI (Mild cognitive impairment) and early alzheimers…its the fact that this story was published in a major news media (okay USATODAY isn’t necessarily quality….but it is popular) for people to see! Not only that…the story actually supports that eating fat and protein is good? Not only are they taking on that controversy….but they also take on the healthy complex carbs and fruits paradigm as well!

Among the foods regarded as complex carbohydrates: rice, pasta, bread and cereals. The digestive system turns them into sugars. Fruits, vegetables and milk products are simple carbs.

“A high-carbohydrate intake could be bad for you because carbohydrates impact your glucose and insulin metabolism,” says Roberts. “Sugar fuels the brain, so moderate intake is good. However, high levels of sugar may actually prevent the brain from using the sugar — similar to what we see with type 2 diabetes.”

WHAT THE HELL IS HAPPENING!!!

TheFatNurse’s Reaction To This Article

To be fair, the study seems to be a prospective descriptive study from how the article describes it, so this really doesn’t tell us anything solid but can be used for generating new hypotheses. This subject interested TheFatNurse enough to explore this new paradigm of glucose and the pathophysiology of Alzheimer’s – a change which is classifying it as Type 3 diabetes. A good recent review on the subject can be found in this 2012 Curr Alzheimer Research review

Growing evidence supports the concept that AD fundamentally represents a metabolic disease in which brain glucose utilization and energy production are impaired. Metabolic abnormalities have been linked to brain insulin and insulin-like growth factor (IGF) resistance with disruption of signaling pathways that regulate neuronal survival, energy production, gene expression, and plasticity.

This idea has been around for awhile but has recently been picking up more steam as new studies are showing more evidence of insulin resistance and alzheimer’s. Earlier this month, NewScientist had diet and alzheimer’s as it’s cover story.

The rigid employment of standardized criteria for diagnosing AD, in fact, restricts our ability to fully comprehend the underlying disease process.

Subsequently, AD was shown to be associated with brain insulin resistance and insulin deficiency, with significant abnormalities in the expression of genes and activation of kinases that are regulated by insulin and insulin-like growth factor (IGF) signaling.

In essence, AD can be regarded as a form of brain diabetes that has elements of both insulin resistance and insulin deficiency. To consolidate this concept, we proposed that AD be referred to as, “Type 3 diabetes

Very interesting stuff and honestly pretty frightening if the increased rates of diabetes in children and adults will turn into increased rates of Alzheimers in the next few decades.

References:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349985/

http://www.ncbi.nlm.nih.gov/pubmed/22810099